English

Efficacy of phage therapy in pigs: systematic review and meta-analysis

Karina Desiree, Sabrina Mosimann, Paul Ebner

 

Limits on the use and efficacy of various antibiotics coupled with negative consumer perception of the practice have together spurred substantial research into compounds that could reduce the use antibiotics to control bacterial diseases in pigs. Bacteriophages are often among such potential compounds, and various groups have examined the efficacy of bacteriophages or bacteriophage products in limiting transmission or colonization of targeted bacteria. The study presented here provides a systematic review of such studies followed by a meta-analysis of aggregated data produced by each study. The data set was limited to inputs (n = 19; 576 total observations) from studies where: 1) live pigs were inoculated with a known quantity of challenge bacteria; 2) challenged animals were treated with a known quantity of phages; 3) concentrations of the challenge bacteria were measured in different tissues/fluids following phage treatment; and 4) SD (or SE to allow calculation of SD) was reported. Concentrations of challenge bacteria were significantly lower in phage treated pigs versus challenged but untreated pigs (P < 0.0001; effect size = −1.06 1log10 colony-forming units [CFU]/g). The effect size of phage treatment was significantly greater (P < 0.05) in samples collected 48 to 96 h following phage treatment versus those collected ≤ 24 h following phage treatment. Likewise, effect size of phage treatment was significantly greater in piglets versus market-weight pigs. Across observations, phage treatment effect sizes were greatest (P < 0.01) in fecal samples versus ileal or cecal samples. Taken together, these data indicate that phage treatment can significantly reduce the concentrations of targeted bacteria in pigs; scenarios exist, however, where phage treatment could predictably be more or less effective.

 

Registration hotline: 021-57634675

fax: 021-57632800

Copy right : 上海亘泰实业集团

Collaboration & Sponsorship: 021-57634938 57631012

ASASHotline:021-67868428

Site Map |   CNZZStatistics

address:Shanghai songjiang jiuting town nine new highway 90 lane 3 nine new commercial building 15 floor

  

WeChat ID:asaschina

The pig nutrition international BBS CSIS

- ×
Registration hotline
021-57631012
黄女士:13651764536
Collaboration & Sponsorship

021-57634938

顾先生:13564244927